Wolf, K and DellaBruna, R and Bruckschlegel, G and Schunkert, H and Riegger, GAJ and Kurtz, A (1996) Angiotensin II receptor gene expression in hypertrophied left ventricles of rat hearts. JOURNAL OF HYPERTENSION, 14 (3). pp. 349-354. ISSN 0263-6352,
Full text not available from this repository.Abstract
Objective To examine the expression of angiotensin II At-1a, AT(1b) and AT(2) receptor genes in the left ventricles of rats subjected to ventricular pressure overloading induced by aortic banding for 6 weeks and then 6 weeks medical treatment. Results Aortic banding was related to an increase in relative weight of the left ventricle from 1.73+/-0.06 (sham-operated) to 2.81+/-0.25 g/kg, an increase in beta-myosin: alpha-myosin messenger RNA (mRNA) ratio from 0.30+/-0.02 to 1.94+/-0.55 and an 18-fold increase in left ventricular atrial natriuretic peptide mRNA levels. In contrast, left ventricular pressure overload hypertrophy was not related to a significant change in the abundance of AT(1a), and AT(1b) mRNA, which were expressed in a relative ratio of 5:1. Similarly, the abundance of AT(2) mRNA was not significantly changed in hypertrophied ventricles. In rats receiving the angiotensin II AT(1) receptor antagonist losartan (40 mg/kg) for 6 weeks after banding, relative heart weights were 2.39+/-0.14 g/kg, the beta-myosin : alpha-myosin ratio was 1.04+/-0.20 and atrial natriuretic peptide mRNA levels displayed a blunted increase (11-fold over sham-treated controls), documenting a significant amelioration of left ventricular hypertrophy by blockade of the AT(1) receptor. Conclusion Losartan treatment in parallel did not affect AT(1a), AT(1b) and AT(2) receptor mRNA levels, which were not different from those in vehicle-treated or sham-treated controls. These findings confirm that left hypertrophy in the rat is associated with ventricular expression of beta-myosin and of atrial natriuretic peptide and with reduced expression of cr-myosin. Despite these significant changes in cardiac gene expression no alteration was observed in AT(1a), AT(1b) and AT(2) receptor mRNA levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPLETE NUCLEOTIDE-SEQUENCE; MYOSIN HEAVY-CHAIN; FULL LENGTH CDNA; CONVERTING ENZYME; MESSENGER-RNA; INHIBITION; CELLS; angiotensin II receptors, atrial natriuretic peptide; hypertrophy; alpha-myosin/beta-myosin; losartan |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51893 |
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