Kuhn, Karl-Heinz and Uhlih, J. and Grubhoffer, L. (1996) Ultrastructural localization of a sialic acid-specific hemolymph lectin in the hemocytes and other tissues of the hard tick Ixodes ricinus (Acari; Chelicerata). PARASITOLOGY RESEARCH, 82 (3). pp. 215-221. ISSN 0932-0113, 1432-1955
Full text not available from this repository.Abstract
Lectins have been suggested to function as pattern-recognition molecules in invertebrate immune mechanisms. A lectin from the hemolymph of the tick Ixodes ricinus with main specificity for sialic acid was characterized and antibodies directed against this lectin were prepared. In this study, these antibodies were used to localize the lectin in the tissues of I. ricinus. Immuno-reactivity with poly- and monoclonal antibodies was detected in the granules of both types of granular hemocytes, at the membrane of hemocytes, and at the basal laminae surrounding the hemocoel. Furthermore, cells attached to the midgut, invaginations of Gene's organ, and granular inclusions of nephrocytes were labeled. The immunoreactivity detected in hemocytes and the hemocoel lining supports the idea that the hemolymph lectin may function as a recognition molecule in the immune system of I. ricinus. Another function could be protection of eggs that are coated with secretions by Gene's organ. The lectin activity could also be involved in transmission of Borrelia burgdorferi, the causative agent of Lyme borreliosis, and the tick-borne encephalitis virus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BORRELIA-BURGDORFERI; GLYCOPROTEINS; BIOLOGY; DOMAINS; GROWTH |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Nov 2023 10:04 |
| Last Modified: | 07 Nov 2023 10:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51901 |
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