Sittinger, M. and Bujia, J. and Rotter, N. and Reitzel, D. and Minuth, Will W. and Burmester, G. R. (1996) Tissue engineering and autologous transplant formation: Practical approaches with resorbable biomaterials and new cell culture techniques. BIOMATERIALS, 17 (3). pp. 237-242. ISSN 0142-9612, 1878-5905
Full text not available from this repository.Abstract
The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the major role of the extracellular matrix and cell differentiation in an artificial tissue. New technical approaches of in vitro tissue engineering are compared to the natural development of tissues in vivo. Current methods using resorbable biomaterials, tissue encapsulation and perfusion culture are discussed. Major consideration is given to scaffold structures of biomaterials that define a three-dimensional shape of a tissue or guide matrix formation. The different goals of tissue engineering such as in vitro models and transplant production are taken into account in the described techniques. Practical concepts comprising cell multiplication and differentiation in subsequent steps for future clinical applications are outlined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTICULAR CHONDROCYTES; CARTILAGE PHENOTYPE; COLLAGEN; MATRIX; INVITRO; MORPHOLOGY; DISEASE; AGAROSE; INVIVO; ACID; tissue engineering; cell transplantation; perfusion culture; extracellular matrix; cartilage |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Will Minuth |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Nov 2023 07:50 |
| Last Modified: | 14 Nov 2023 07:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51950 |
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