Ott, MG and Mannel, DN and Gallati, H and Goerig, M and Raeth, U (1996) Peripheral natural killer cell activity and intraperitoneal soluble p55 tumor necrosis factor receptor in patients with malignant ascites: Two possible indicators for response to intraperitoneal combined tumor necrosis factor alpha and interferon gamma treatment. CANCER IMMUNOLOGY IMMUNOTHERAPY, 42 (1). pp. 31-37. ISSN 0340-7004, 1432-0851
Full text not available from this repository.Abstract
Tumor necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) are important immunomodulators. They are capable of acting in a synergistic manner on tumor cells in vitro and in vivo. In a clinical phase I study 13 patients with malignant ascites due to abdominal spread of different primary tumors received intraperitoneally (i.p.) TNF alpha and IFN gamma once weekly over 3-8 weeks in order to evaluate the effect of locoregionally administered TNF alpha/IFN gamma on ascites formation. Therefore some peripheral and local immunological functional parameters of peripheral blood and malignant ascites were investigated. Mononuclear lymphocytes and natural killer (NK) cell activity of peripheral blood and ascites, TNF-inhibitory activity, soluble p55 and p75 TNF receptors, and prostaglandin E(2) values in ascites were measured immediately before and 24 h after each TNF alpha/IFN gamma infusion. Peripheral mononuclear lymphocytes and NK activity decreased significantly 24 h after i.p. TNF alpha/IFN gamma application. However, over the entire treatment schedule, peripheral NK activity in all responders showed a continuous increase, when compared to pre TNF alpha/IFN gamma treatment levels. In contrast, NK activity in non-responders constantly decreased. In contrast to non-responders, TNF-inhibitory activity and soluble p55 TNF receptor levels, determined in ascites, decreased in responders. Taken together, our findings suggest, that successful locoregional i.p. TNF alpha/IFN gamma therapy induces systemic immunological reactions possibly after saturation of soluble p55 TNF receptors in ascites, which leads to an increase of peripheral NK activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTITUMOR ACTIVITIES; OVARIAN-CANCER; SERUM LEVELS; LYMPHOTOXIN; INDUCTION; STIMULATION; INHIBITION; ENDOTOXIN; CYTOKINES; BINDING; tumor necrosis factor alpha; interferon gamma; NK cell activity; soluble TNF receptors; malignant ascites |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52021 |
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