Szeimies, RM and Karrer, S and Sauerwald, A and Landthaler, M (1996) Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: An initial clinical study. DERMATOLOGY, 192 (3). pp. 246-251. ISSN 1018-8665,
Full text not available from this repository.Abstract
Background: The incidence of actinic keratoses (AK) is rising and there is still a need for therapeutic alternatives. Objective: To demonstrate the efficacy and tolerability of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) in the treatment of AK. Methods: Ten patients with 36 lesions (19 at hands and arms, 17 on the head) received ALA-PDT once (occlusive application of a 10% ALA emulsion for 6 h, irradiation with red light, 580-740 nm, 150 J/cm(2)) and were then monitored for 3 months. Therapeutic efficacy was judged using a score evaluating infiltration and keratosis of AK. Results: After 28 days, significantly lower score sums were observed (head: mean=15%; hand: mean=67%) compared to the initial score (100%). Complete remission was achieved in 71% of AK localized on the head, No notable side effects were observed. Conclusion: This study demonstrated the potential of good efficacy and tolerability in the treatment of AK using topical ALA-PDT. How efficacy for lesions on the hand can be improved and whether PDT is able to concur with established treatment modalities remains to be shown in further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOGENOUS PROTOPORPHYRIN; CELL CARCINOMA; DOUBLE-BLIND; 5-FLUOROURACIL; CREAM; photodynamic therapy; 5-aminolevulinic acid; actinic keratoses |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52030 |
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