The combined effects of high-energy shock waves and ionising radiation on a human bladder cancer cell line

Fickweiler, S and Steinbach, P and Worle, K and Hofstadter, F (1996) The combined effects of high-energy shock waves and ionising radiation on a human bladder cancer cell line. ULTRASOUND IN MEDICINE AND BIOLOGY, 22 (8). pp. 1097-1102. ISSN 0301-5629,

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Abstract

The effects of high-energy shock waves (HESW) generated by an experimental Siemens lithotripter in combination with Cs-137 gamma-rays were examined in vitro. Proliferation after treatment of immobilised pellets of either single cells or multicellular spheroids of the bladder cancer cell line RT4 was determined using colony-forming assays and cell cycle analysis, Surviving and cell cycle fractions were calculated for each shock wave and radiation application mode separately, and for sequential combination in different successions for the purpose of characterizing the interaction of both treatment modalities, Combination of HESW and ionising radiation turned out to act additively or slightly supra-additively on both biologic models. Copyright (C) 1996 World Federation for Ultrasound in Medicine & Biology

Item Type: Article
Uncontrolled Keywords: TUMOR-GROWTH; INVITRO; HYPERTHERMIA; IRRADIATION; EXPOSURE; DAMAGE; INVIVO; FLOW; combination treatment; high-energy shock waves; ionising radiation; bladder cancer cell line; single cells; multicellular tumour spheroids; clonogenicity; cell cycle analysis
Depositing User: Dr. Gernot Deinzer
Last Modified: 19 Oct 2022 08:36
URI: https://pred.uni-regensburg.de/id/eprint/52135

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