Schlegel, Jürgen and Stumm, Gabi and Scherthan, Harry and Bocker, Tina and Zirngibl, Hubert and Rüschoff, Josef and Hofstädter, Ferdinand (1995) Comparative Genomic in Situ Hybridization of Colon Carcinomas with Replication Error. CANCER RESEARCH, 55 (24). pp. 6002-6005. ISSN 0008-5472, 1538-7445
Full text not available from this repository.Abstract
The aim of the present study was to detect complex; genetic alterations in colorectal carcinomas with and without microsatellite instability (MIN) by comparative genomic in situ hybridization, MIN due to replication errors is the hallmark of hereditary nonpolyposis colon cancer, None of 6 MIN-positive tumors showed amplifications, and only 2 tumors displayed deletions of one chromosomal segment each, In contrast, different gains and losses were observed in 11 of 12 MIN-negative carcinomas, The most frequent gains affected chromosomes 7, 13, and 20q, whereas deletions were observed on chromosomes 17, 18, and 9p, These results demonstrate different mechanisms of genetic instability in subgroups of colorectal carcinomas and may, therefore, support the hypothesis of different etiologies in tumors with and without MIN.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLORECTAL-CANCER; INSTABILITY; MUTATIONS; SEQUENCES; HOMOLOG |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Feb 2025 10:49 |
| Last Modified: | 27 Feb 2025 10:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52159 |
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