RUPPRECHT, HJ and TERRES, W and OZBEK, C and LUZ, M and JESSEL, A and HAFNER, G and DAHL, JV and KROMER, EP and PRELLWITZ, W and MEYER, J (1995) RECOMBINANT HIRUDIN (HBW-023) PREVENTS TROPONIN-T RELEASE AFTER CORONARY ANGIOPLASTY IN PATIENTS WITH UNSTABLE ANGINA. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 26 (7). pp. 1637-1642. ISSN 0735-1097,
Full text not available from this repository.Abstract
Objectives. This study was performed to evaluate the efficacy of peri-interventional treatment with recombinant hirudin (r-hirudin [HEW 023]) compared with heparin in the prevention of troponin T release in patients with unstable angina. Background. Percutaneous transluminal coronary angioplasty in patients with unstable angina is associated with a high risk of acute thrombotic complications. Methods. Serial troponin T measurements mere performed in 61 patients with unstable angina during the 48-h observation period after coronary angioplasty of the ischemia-related lesion. Patients were randomly assigned to peri-interventional intravenous treatment with either r-hirudin (dosage group I: 0.3-mg/kg body weight bolus, 0.12 mg/kg per h for 24 h; dosage group II: 0.5-mg/kg bolus, 0.24 mg/kg per h for 24 h) or heparin (150-IU/kg bolus, 20 IU/kg per h for 24 h). All patients received acetylsalicylic acid before coronary angiography. After 24 h, patients received a constant low dose infusion of either hirudin (0.04 mg/kg per h) or heparin (7 IU/kg per h) for another 24 h. The power of the study to detect a decrease in abnormal troponin T levels from 60% (heparin group) to 20% (combined r-hirudin groups),vas 88%. Results. Serial troponin T measurements revealed two peaks within the 48 h after coronary angioplasty in the heparin but not the hirudin groups. An elevated serum troponin T concentration (>0.2 ng/ml) within 48 h of coronary angioplasty was found in 9 (24%) of 38 patients in the hirudin groups (5 [25%] of 20 in dosage group I; 4 [22%] of 18 in dosage group II) compared,vith 11 (58%) of 19 in the heparin group (p = 0.01). We observed major cardiac events (death, myocardial infarction, abrupt vessel closure) in 1 (4.8%) of 21 patients in dosage group I, 1 (5.3%) of 19 in dosage group IT and 3 (14.3%) of 21 in the heparin group (p = 0.33). Conclusions. In this pilot trial, hirudin appears to be superior to heparin in preventing troponin T release after coronary angio plasty. (J Am Coll Cardiol 1995;26:1637-42)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THROMBIN INHIBITOR; HEPARIN-THERAPY; PECTORIS; OCCLUSION; THROMBOLYSIS; ANTITHROMBIN; INFARCTION; CGP-39393; PLATELETS; SAFETY; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52190 |
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