Karl, Alexander and Buchner, Alexander and Tympner, Christiane and Kirchner, Thomas and Ganswindt, Ute and Belka, Claus and Ganzer, Roman and Wieland, Wolf and Eder, Fabian and Hofstaedter, Ferdinand and Schilling, David and Sievert, Karl-Dietrich and Stenzl, Arnulf and Scharpf, Marcus and Fend, Falko and vom Dorp, Frank and Ruebben, Herbert and Schmid, Kurt Werner and Porres-Knoblauch, Daniel and Heidenreich, Axel and Hangarter, Birgit and Knuechel-Clarke, Ruth and Rogenhofer, Michael and Wullich, Bernd and Hartmann, Arndt and Comploj, Evi and Pycha, Armin and Hanspeter, Esther and Pehrke, Dirk and Sauter, Guido and Graefen, Markus and Gratzke, Christian and Stief, Christian and Wiegel, Thomas and Haese, Alexander (2015) Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study. RADIOTHERAPY AND ONCOLOGY, 116 (1). pp. 119-124. ISSN 0167-8140, 1879-0887
Full text not available from this repository. (Request a copy)Abstract
Background and purpose: Positive surgical margins (PSM) after radical prostatectomy have been shown to be associated with impaired outcome. In pT3pN0 patients with PSM either immediate radiotherapy or clinical and biological monitoring followed by salvage radiotherapy is recommended by the latest guidelines of the European Association of Urology. Materials and methods: A retrospective, multicenter study of eight urological centers was conducted on 536 prostatectomy patients with pT3aN0/NxR1 tumors and no neoadjuvant/adjuvant therapy. A pathological re-review of all prostate specimens was performed. Association of clinical and pathological features with biochemical recurrence (BCR) was analyzed using univariate and multivariate analysis. Results: With 48 months median follow-up, BCR occurred in 39.7%. Preoperative PSA value, performance of pelvic lymph node dissection and Gleason score were significantly associated with BCR. In multivariate analysis, Gleason score was the only independent prognostic factor (p < 0.001) for BCR. Five-year BCR-free survival rates were 74%, 70%, 38%, and 51% with Gleason score 6,3 + 4 = 7a, 4 + 3 = 7b, and 8-10, respectively. Conclusions: In pT3aN0/NxR1 patients with no adjuvant/neoadjuvant treatment, Gleason Score permits independent prediction of the risk for BCR. These findings could help to estimate and discuss the individual risk for BCR with our patients on an individual basis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SALVAGE RADIATION-THERAPY; RADICAL PROSTATECTOMY; ADJUVANT RADIOTHERAPY; MULTIINSTITUTIONAL ANALYSIS; POSTOPERATIVE RADIOTHERAPY; GRADE; SPECIMENS; PREDICTOR; SURVIVAL; LOCATION; Localized prostate cancer; Surgical margins; Adjuvant therapy; Prognostic parameters |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2019 07:18 |
| Last Modified: | 08 Jul 2019 07:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5228 |
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