Schatz, Valentin and Neubert, Patrick and Schroeder, Agnes and Binger, Katrina and Gebhard, Matthias and Mueller, Dominik N. and Luft, Friedrich C. and Titze, Jens and Jantsch, Jonathan (2017) Elementary immunology: Na+ as a regulator of immunity. PEDIATRIC NEPHROLOGY, 32 (2). pp. 201-210. ISSN 0931-041X, 1432-198X
Full text not available from this repository. (Request a copy)Abstract
The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases with age, inflammation and infection. This increased local Na+ availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na+ availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na+ levels bears broad therapeutic potential: increasing local Na+ availability may help in treating infections, while lowering tissue Na+ levels may be used to treat, for example, autoimmune and cardiovascular diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SALT-SENSITIVE HYPERTENSION; LYMPHATIC VESSEL DENSITY; PATHOGENIC T(H)17 CELLS; PROTEIN-KINASE P38; DENDRITIC CELLS; T-CELLS; TISSUE SODIUM; RENAL MEDULLA; ALTERNATIVE ACTIVATION; OSMOTIC SURVEILLANCE; Local Na+ availability; Skin salt storage; Macrophages; T cells; Immune cell function and activation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 20 Oct 2020 10:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/523 |
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