Della Bruna, Roberto and Schricker, Karin and Holmer, Stephan and Kurtz, Armin (1995) Rat renin gene transcription is initiated at a single start site. FEBS LETTERS, 372 (2-3). pp. 157-160. ISSN 0014-5793, 1873-3468
Full text not available from this repository.Abstract
The promoter region of the renin gene in man, mouse and rat contains several putative transcription start sites, which in mouse have been shown to be tissue specific and differently regulated, To investigate which of these start sites are used during stimulation of renin gene transcription by the major physiological control factors, we determined the trancription start sites of rat renin in the kidney and adrenal glands by RNase protection using a cRNA probe spanning 387 bases upstream and 121 bases downstream from the canonical transcription initiation site. To stimulate renin gene expression, we used renal artery stenosis, angiotensin II antagonists, furosemide and isoprenaline infusions and low sodium diet, Our results suggest that only one TATA box is functional in rat kidney and adrenal.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA LEVELS; MOLECULAR-BIOLOGY; DIETARY NACL; EXPRESSION; KIDNEY; TISSUE; MICE; HYPERTENSION; FUROSEMIDE; SECRETION; RENIN PROMOTER; TATA BOX; MESSENGER-RNA LEVEL |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Jan 2024 09:57 |
| Last Modified: | 04 Jan 2024 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52311 |
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