Knieps, Sebastian and Michel, Martin C. and Dove, Stefan and Buschauer, Armin (1995) Non-peptide neuropeptide y antagonists derived from the histamine H2 agonist arpromidine: Role of the guanidine group. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 5 (18). pp. 2065-2070. ISSN 0960-894X, 1464-3405
Full text not available from this repository.Abstract
Arpromidine analogs in which the guanidino group was replaced or substituted were investigated in functional studies for NPY Y-1 and histamine H-1 antagonism as well as for H-2 agonism (HEL cells, guinea pig ileum and atrium). A basic guanidine or amidine system proved to be important for both Y-1 and H-2 receptor activity. Additional guanidine substitution (Me, cHex, Ph) is compatible with Y-1 antagonism but not with high H-2 agonist potency.
| Item Type: | Article |
|---|---|
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2024 05:55 |
| Last Modified: | 16 Jan 2024 05:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52312 |
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