Gust, Ronald and Bernhardt, Gunther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schoenenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the ''third generation platinum complex'' [(+/-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) .1. Preparation and studies on the stability and antitumor activity. ARCHIV DER PHARMAZIE, 328 (9). pp. 645-653. ISSN 0365-6233, 1521-4184
Full text not available from this repository.Abstract
The development of a galenical formulation for poorly water soluble dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+/-)-1,2-bis(4-fluorophenyl)ethlenediamine]dichloroplatinum(II) (rac-4F-PtCl2), is based on the reaction of a soluble diaquaplatinum(II) salt with sodium chloride in water in the presence of pluronic F 68 as stabilizer and results in a sufficiently stable colloidal solution (i.e. hydrosol). In contrast to the poorly water soluble synthetic rac-4F-PtCl2, which was ineffective towards the hormone sensitive MXT-M-3.2 breast cancer of the mouse, its hydros of formulation proved to be highly active and was very well tolerated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INHIBITING <1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE>PLATINUM(II) COMPLEXES; CELL-LINE; CISPLATIN; ACCUMULATION; CARCINOMA; Pt-complex solubilization; hydrosol breast cancer inhibiting properties |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2024 06:46 |
| Last Modified: | 16 Jan 2024 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52323 |
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