HAUPT, W and HOHENBERGER, W and KLEIN, P and CHRISTOU, NV (1995) DETECTION OF NEOPTERIN, INTERLEUKIN-6 AND ACUTE-PHASE PROTEINS AS PARAMETERS OF POTENTIAL MONOCYTE ACTIVATION IN PREOPERATIVE PATIENTS. INFECTION, 23 (5). pp. 263-266. ISSN 0300-8126,
Full text not available from this repository.Abstract
Monocytes play a key role in the immune response to trauma and infection. Is monocyte function already altered before surgery in terms of cell activation? On admission, serum neopterin was at or above 9 nmol/l in 50.2% and serum IL-6 was detectable (> 4 pg/ml) in 10.5% of 227 patients electively undergoing major abdominal surgery. Mean values of CRP (0.8 vs. 3.6), alpha-1-antitrypsin (267 vs. 376), albumin (4.0 vs. 3.5), prealbumin (27.0 vs, 17.9, all at p < 0.01) were significantly different in patients with or without monocyte activation (neopterin > 9 nmol/l and IL-6 > 4 pg/ml). There was a significant correlation between neopterin and the acute phase proteins (all at p < 0.01). The data reflect a ''primed'' state at least of some parts of the immune system in a subgroup of preoperative patients potentially affecting their response to surgical trauma and bacterial contamination.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; PROSTAGLANDIN-E2 PRODUCTION; ENDOTOXIN TOLERANCE; HUMAN HEPATOCYTES; PLASMA-LEVELS; SEPSIS; CYTOKINES; CACHECTIN; RELEASE; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52341 |
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