SCHRICKER, K and HEGYI, I and HAMANN, M and KAISSLING, B and KURTZ, A (1995) TONIC STIMULATION OF RENIN GENE-EXPRESSION BY NITRIC-OXIDE IS COUNTERACTED BY TONIC INHIBITION THROUGH ANGIOTENSIN-II. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 92 (17). pp. 8006-8010. ISSN 0027-8424,
Full text not available from this repository.Abstract
This study was designed to examine the possible involvement of prostaglandins and nitric oxide (NO) in the renin stimulatory effect of angiotensin II (AngII) antagonists, To this end, plasma renin activities (PRAs) and renal renin mRNA levels were assayed in rats that were treated with the Ang-converting enzyme inhibitor ramipril or with the AngII. AT(1)-receptor antagonist losartan. Ramipril and losartan increased PRA values from 7.5 +/- 1.6 to 86 +/- 6 and 78 +/- 22 ng of AngI per h per mi and renin mRNA levels from 112 +/- 9% to 391 +/- 20% and 317 +/- 10%, respectively, Inhibition of prostaglandin formation with indomethacin did not influence basal or ramipril-affected PRA. Basal renin mRNA levels also were unchanged by indomethacin, while increases in renin mRNA levels after ramipril treatment were slightly reduced by indomethacin, Inhibition of NO synthase by nitro-L-arginine methyl ester (L-NAME) reduced PRA values to 3.2 +/- 0.9, 34 +/- 13, and 12.1 +/- 2.7 ng of AngI per h per mi in control, ramipril-treated, and losartan-treated animals, respectively, Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME, The AngII antagonists, furthermore, induced an upstream recruitment of renin-expressing cells in the renal afferent arterioles, which was also blunted by L-NAME. These findings suggest that renin mRNA levels are tonically increased by NO and that the action of NO is counteracted by AngII.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CULTURED ENDOTHELIAL-CELLS; MESSENGER-RNA LEVELS; RELAXING FACTOR; CONVERTING ENZYME; JUXTAGLOMERULAR CELLS; RAT-KIDNEY; RELEASE; SECRETION; SYNTHASE; PROSTACYCLIN; NITRIC OXIDE SYNTHASE; JUXTAGLOMERULAR CELLS; PROSTAGLANDINS; RAMIPRIL; LOSARTAN |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52385 |
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