Aune, Dagfinn and Norat, Teresa and Leitzmann, Michael and Tonstad, Serena and Vatten, Lars Johan (2015) Physical activity and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 30 (7). pp. 529-542. ISSN 0393-2990, 1573-7284
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We investigated the association between specific types of physical activity and the risk of type 2 diabetes in a systematic review and meta-analysis of published studies. PubMed, Embase and Ovid databases were searched for prospective studies and randomized trials up to 2nd of March 2015. Summary relative risks (RRs) were calculated using a random effects model. Eighty-one studies were included. The summary RRs for high versus low activity were 0.65 (95 % CI 0.59-0.71, I-2 = 18 %, n = 14) for total physical activity, 0.74 (95 % CI 0.70-0.79, I-2 = 84 %, n = 55) for leisure-time activity, 0.61 (95 % CI 0.51-0.74, I-2 = 73 %, n = 8) for vigorous activity, 0.68 (95 % CI 0.52-0.90, I-2 = 93 %, n = 5) for moderate activity, 0.66 (95 % CI 0.47-0.94, I-2 = 47 %, n = 4) for low intensity activity, and 0.85 (95 % CI 0.79-0.91, I-2 = 0 %, n = 7) for walking. Inverse associations were also observed for increasing activity over time, resistance exercise, occupational activity and for cardiorespiratory fitness. Nonlinear relations were observed for leisure-time activity, vigorous activity, walking and resistance exercise (p (nonlinearity) < 0.0001 for all), with steeper reductions in type 2 diabetes risk at low activity levels than high activity levels. This meta-analysis provides strong evidence for an inverse association between physical activity and risk of type 2 diabetes, which may partly be mediated by reduced adiposity. All subtypes of physical activity appear to be beneficial. Reductions in risk are observed up to 5-7 h of leisure-time, vigorous or low intensity physical activity per week, but further reductions cannot be excluded beyond this range.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIFE-STYLE FACTORS; MIDDLE-AGED MEN; BODY-MASS INDEX; IMPAIRED FASTING GLUCOSE; CORONARY-HEART-DISEASE; 20-YEAR FOLLOW-UP; CARDIORESPIRATORY FITNESS; GENERAL-POPULATION; POSTMENOPAUSAL WOMEN; WHITEHALL II; Physical activity; Sports; Exercise; Walking; Type 2 diabetes; Systematic review; Meta-analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2019 08:31 |
| Last Modified: | 08 Jul 2019 08:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5239 |
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