FISCHER, E and LANG, B (1995) SYSTEMIC-SCLEROSIS - RECOMMENDATIONS FOR PHARMACOTHERAPY. CLINICAL IMMUNOTHERAPEUTICS, 4 (2). pp. 93-102. ISSN 1172-7039,
Full text not available from this repository.Abstract
Increased collagen production by fibroblasts and collagen accumulation in small arteries, microvasculature, the subcutis and the tissue of several organs is the central pathological feature of systemic sclerosis. Disease-modifying therapies are tried with the aim of reducing collagen production. Penicillamine interferes with the post-translational modification of collagen fibres. Immunosuppressive drugs modulate the activity of lymphocytes, monocytes and mast cells, which stimulate fibroblast proliferation. Organ complications have to be treated independently. This article discusses the clinical features of organ involvement as well as assessment, drug therapy and supportive measures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAYNAUDS-PHENOMENON; GAMMA-INTERFERON; SCLERODERMA; CYCLOSPORINE; NIFEDIPINE; DISEASE; TRIAL; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52396 |
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