MITTERER, M and PESCOSTA, N and FEND, F and LARCHER, C and PRANG, N and SCHWARZMANN, F and COSER, P and HUEMER, HP (1995) CHRONIC ACTIVE EPSTEIN-BARR-VIRUS DISEASE IN A CASE OF PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS. BRITISH JOURNAL OF HAEMATOLOGY, 90 (3). pp. 526-531. ISSN 0007-1048,
Full text not available from this repository.Abstract
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare haematological disorder. It is characterized by activated and morphologically atypical B lymphocytes and polyclonal IgM production and has been associated with female sex, cigarette smoking, and HLA-DR7 expression. We report a case of PPBL with intermitting symptoms compatible with a chronic fatigue syndrome, recurrent erythema nodosum and multiforme. Serological findings suggest-ed a chronic active Epstein-Barr virus (EBV) infection. Messenger RNA of EBV immediate early gene transactivation BZLF1 was detected in peripheral blood lymphocytes by reverse transcriptase PCR indicating a persistent replication of the virus. Over 2 years of observation we detected varying numbers of atypical lymphocytes. These cells hybridized with a probe specific for the EBV internal repeat region (BamHI W) which indicates a productive infection. Of interest, no reaction was observed with a probe specific for the latency-associated small RNAs (EBERs). The immunological phenotype of the polyclonal B cells was similar to B-cell lines immortalized by EBV in vitro, expressing a number of activation molecules (CD23, CD25, CD54) and the bcl-2 protein. In summary, our findings suggest that persistent EBV replication might be crucial in the development of lymphoproliferative disorders such as PPBL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIGARETTE-SMOKING; RISK-FACTORS; LATENT; GENE; PPBL; LYMPHOCYTOSIS; CHRONIC ACTIVE EBV; HLA-DR7 |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52443 |
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