JILG, W and SIEGER, E and ZACHOVAL, R and SCHATZL, H (1995) INDIVIDUALS WITH ANTIBODIES AGAINST HEPATITIS-B CORE ANTIGEN AS THE ONLY SEROLOGICAL MARKER FOR HEPATITIS-B INFECTION - HIGH PERCENTAGE OF CARRIERS OF HEPATITIS-B AND HEPATITIS-C VIRUS. JOURNAL OF HEPATOLOGY, 23 (1). pp. 14-20. ISSN 0169-5185,
Full text not available from this repository.Abstract
Background/Aims: Several reports have unequivocally demonstrated that some indi,iduals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection are chronic carriers of the hepatitis B virus, Nevertheless, conflicting data exist about the frequency of this phenomenon; its cause is unknown. Methods: In a prospective study we tested individuals who were positive for anti-HBc alone for HBV-DNA as well as for coexisting infections with human immunodeficiency virus and hepatitis C virus. Results: Using polymerase chain reaction with primer pairs from three different regions of the hepatitis B virus genome, we found 54 of 164 individuals (32.9%) with anti-HBc alone to be positive for hepatitis B virus, the majority of them showing very low hepatitis B virus concentrations, 14.3% were human immunodeficiency virus positive; half of them were also hepatitis B virus carriers, Surprisingly, 62 of 153 participants (40.5%) in this study showed antibodies against hepatitis C virus, and about two thirds of the latter were also positive for HCV-RNA, This finding could be confirmed by a retrospective analysis of all people tested for hepatitis B virus markers and anti-HCV in our institution during the 2 gears before the prospective study was begun, Again, a high correlation was found between the presence of anti-HCV and anti-HBc alone: 49.2% of individuals with anti-HBc only were anti-HCV positive also, compared to 26.8% of HBsAg carriers and only 10% of individuals showing the serological pattern of past hepatitis B. Conclusions: Thus our study of individuals positive for anti-HBc alone revealed a high number of carriers of hepatitis B virus and hepatitis C virus among them; furthermore, me found some evidence that hepatitis C virus infection may favour this unusual hepatitis B virus marker pattern. (C) Journal of Hepatology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYMERASE CHAIN-REACTION; VOLUNTEER BLOOD-DONORS; SURFACE-ANTIGEN; NON-A; NUCLEOTIDE-SEQUENCES; ENZYME-IMMUNOASSAY; LIVER-DISEASE; VIRAL-DNA; HBC; SUPERINFECTION; HBV AND HCV DOUBLE INFECTIONS; HBV-DNA; HEPATITIS B VIRUS, CHRONIC CARRIERS; HEPATITIS C VIRUS, CHRONIC CARRIERS; HIV INFECTION; ISOLATED ANTI-HBC; LOW LEVEL CARRIERS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52455 |
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