KUNZ, J and KRAUSE, D and GEHRMANN, J and DERMIETZEL, R (1995) CHANGES IN THE EXPRESSION PATTERN OF BLOOD-BRAIN BARRIER-ASSOCIATED PERICYTIC AMINOPEPTIDASE-N (PAP-N) IN THE COURSE OF ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. JOURNAL OF NEUROIMMUNOLOGY, 59 (1-2). pp. 41-55. ISSN 0165-5728, 1872-8421
Full text not available from this repository.Abstract
The role of cerebral pericytes in blood-brain barrier (BBB) mechanisms is still a matter of controversy. Because acute experimental autoimmune encephalomyelitis (EAE) is characterized by a transient and focal perturbation of the BBB, we have utilized the model of adoptive transfer EAE to correlate the expression of the pericytic aminopeptidase N (pAP N) with the acute functional state of the BBB. We demonstrate that a significant downregulation of microvascular pAP N expression occurs, and the observed perturbation of the enzymatic BBB complement seems to be a sustained effect which persists even after recovery from clinical disease. At the peak of clinical disease, numerous pAP N expressing invasive cells were detected in white matter of the lumbar spinal cord. Through the use of a panel of different immunocytochemical markers these pAP N-immunopositive cells were characterized as ED 1-positive, most likely hematogenous macrophages. Activated resident microglial cells participate in the EAE-induced inflammatory process to only a minor extent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; GAMMA-GLUTAMYL-TRANSPEPTIDASE; MARROW-DERIVED ELEMENTS; LYMPHOCYTE-T LINES; PERIVASCULAR CELLS; CEREBRAL MICROVASCULATURE; ENDOTHELIAL-CELLS; SUBSTANCE-P; RAT-BRAIN; BLOOD-BRAIN BARRIER; PERICYTE; AMINOPEPTIDASE N; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52502 |
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