KRAMER, BK and RITTHALER, T and ACKERMANN, M and SCHRICKER, K and RIEGGER, GAJ and KURTZ, A (1995) RENIN RELEASE OF JUXTAGLOMERULAR CELLS DEPENDING ON ENDOTHELIAL MEDIATORS AND COCULTURE WITH ENDOTHELIAL-CELLS. NIEREN-UND HOCHDRUCKKRANKHEITEN, 24 (6). pp. 308-310. ISSN 0300-5224,
Full text not available from this repository.Abstract
Endogenous NO formed by vascular endothelial cells is capable of stimulating renin secretion from juxtaglomerular cells since absence of 1-arginine or presence of the inhibitor of NO synthase N<(omega)over bar>-nitro-1-arginine (200 mu M) reduces renin release from co-cultures of juxtaglomerular cells with endothelial cells but not from primary cultures of juxtaglomerular cells. Exogenous NO (10-100 mu M sodium nitroprusside or 100 mu M-10 mM SIN-1) also stimulates renin secretion from primary cultures of juxtaglomerular cells as well as from co-culture with endothelial cells. Co-culture per se is associated with a reduction of renin release. This inhibition might be caused in part by endothelin since endothelin isoforms 1-3 (1 mu M each) have been shown to inhibit cAMP-induced (10 mu M forskolin) renin secretion. The made of NO's action on renin release remains to be clarified (slow-acting, independent of cGMP or cAMP, dependent on extracellular calcium).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; RENIN; NO (NITRIC OXIDE); ENDOTHELIN; JUXTAGLOMERULAR CELLS; COCULTURE |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52510 |
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