SPRAY, DC and DERMIETZEL, R (1995) X-LINKED DOMINANT CHARCOT-MARIE-TOOTH DISEASE AND OTHER POTENTIAL GAP-JUNCTION DISEASES OF THE NERVOUS-SYSTEM. TRENDS IN NEUROSCIENCES, 18 (6). pp. 256-262. ISSN 0166-2236, 1878-108X
Full text not available from this repository.Abstract
Gap junctions play important roles in the exchange of information and metabolites in the nervous system, These roles are highlighted by a peripheral neuropathy (X-linked dominant Charcot-Marie-Tooth disease) that is associated with mutations in a gap-junction protein (connexin32), resulting in loss of function, and by somatic dysfunctions where changes in expression, organization or function of gap junctions are associated with neuronal hyper- or hypoexcitability, In this review, the causes and consequences of this gap-junction-related peripheral neuropathy and other pathological conditions of the nervous system, where dysfunctions of junctional communication are considered to play a causal role, are considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CULTURED ASTROCYTES; HORIZONTAL CELLS; PROTEIN; GENE; CHANNEL; GROWTH; EXPRESSION; MUTATIONS; CURRENTS; MEMBRANE; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52521 |
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