KAMMERMEIER, T and WIEGREBE, W (1995) 1,3-DIPHENYLPROPANE-1,3-DIAMINES .5. DNA-INTERACTION, ESTROGEN-RECEPTOR AFFINITY, AND CYTOSTATIC ACTIVITY OF 1,3-DIPHENYLPROPANE-1,3-DIAMINE-PT(II) COMPLEXES. ARCHIV DER PHARMAZIE, 328 (5). pp. 409-415. ISSN 0365-6233,
Full text not available from this repository.Abstract
The Pt(II) complexes of 1,3-diphenylprapan 1,3-diamines (part IV (2))) were tested for DNA interaction (UV-difference spectroscopy, Tables 1 and 2), for affinity to the estrogen receptor (calf uterus cytosol; scarcely any affinity), and for cytostatic activity at estrogen independent MDA-MB 231 cells (Tables 3 and 4) and estrogen dependent MCF-7 cells (Tables 5 and 6). The data are compared with those reported for the analogous 1,2-diphenylethane-1,2-diamine-Pt(II) complexes: most probably, the cytostatic activity is not mediated by the estrogen receptor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER-CELLS; TUMOR-INHIBITING PROPERTIES; PLATINUM-COMPOUNDS; MODEL SYSTEMS; MCF-7 CELLS; LINE; INVITRO; RING; CHEMOSENSITIVITY; ANTIESTROGENS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52549 |
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