Coccolini, F. and Catena, F. and Glehen, O. and Yonemura, Y. and Sugarbaker, P. H. and Piso, P. and Montori, G. and Ansaloni, L. (2015) Complete versus incomplete cytoreduction in peritoneal carcinosis from gastric cancer, with consideration to PCI cut-off. Systematic review and meta-analysis. EJSO, 41 (7). pp. 911-919. ISSN 0748-7983, 1532-2157
Full text not available from this repository. (Request a copy)Abstract
Introduction: The completeness of cytoreduction has been considerated as fundamental in increasing the life expectancy in patients with peritoneal carcinosis (PC) in gastric cancer. However no defintive data about the real effect of complete cytoreduction (CC) have still been published. Moreover. the PCI cut-off to attempt CC with a reasonable-risk-benefit ratio still lacks. Material and methods: A systematic review with meta-analysis of trials of complete vs incomplete cytoreduction in patients with peritoneal carcinosis from GC was performed. Results: Nine trials have been included (748 patients: 417 with CC0-CC1 and 324 with CC2-CC3 cytoreduction). 1, 2, 3 and 5 years survival is favorable to CC0-CC1 (Risk Ratio: 2.41, 8.18, 8.66, and 7.96 respectively). CC0 vs. CC1 survival benefit at 1 and 3 years: RR 2.28 and 6.36 respectively, favoring CC0. 1, 2, 3 and 5 years survival changes significantly above and below a PCI of 12. Conclusions: 1, 2, 3 and 5-year overall survival is increased by CC0-CC1 cytoreduction in patients with PC from gastric origin. Moreover CC0 increases the 1 and 3 years survival when compared to CC1 cytoreduction. (C) 2015 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; ADVANCED ESOPHAGOGASTRIC CANCER; BIDIRECTIONAL CHEMOTHERAPY; PERIOPERATIVE CHEMOTHERAPY; SEROSAL INVASION; CLINICAL-TRIALS; PHASE-III; SURGERY; CARCINOMATOSIS; DISSEMINATION; Gastric cancer; Cytoreduction; Carcinosis; Surgery; Meta-analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2019 09:19 |
| Last Modified: | 08 Jul 2019 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5257 |
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