IN-111-OXINE LABELING OF TUMOR-CYTOTOXIC MACROPHAGES GENERATED IN-VITRO FROM CIRCULATING BLOOD MONOCYTES - AN IN-VITRO EVALUATION

MARIENHAGEN, J and HENNEMANN, B and ANDREESEN, R and EILLES, C (1995) IN-111-OXINE LABELING OF TUMOR-CYTOTOXIC MACROPHAGES GENERATED IN-VITRO FROM CIRCULATING BLOOD MONOCYTES - AN IN-VITRO EVALUATION. NUCLEAR MEDICINE COMMUNICATIONS, 16 (5). pp. 357-361. ISSN 0143-3636,

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Abstract

The labelling of ex-vivo activated macrophages with doses of In-111-oxine sufficient for gamma camera imaging does not damage cell viability or the functional competence of cells (secretion of tumour necrosis factor-alpha and interleukin-6). The mean labelling efficiency was about 84%. Release of In-111 equivalent to 15% occurred over 24 h under cell culture conditions, indicating good stability of the radioactive cell label. In-111-oxine-labelled macrophages are a suitable tool for biokinetic studies of adoptive immunotherapy.

Item Type: Article
Uncontrolled Keywords: ;
Depositing User: Dr. Gernot Deinzer
Last Modified: 19 Oct 2022 08:37
URI: https://pred.uni-regensburg.de/id/eprint/52572

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