ELSNER, D and MUDERS, F and MUNTZE, A and KROMER, EP and FORSSMANN, WG and RIEGGER, GAJ (1995) EFFICACY OF PROLONGED INFUSION OF URODILATIN [ANP-(95-126)] IN PATIENTS WITH CONGESTIVE-HEART-FAILURE. AMERICAN HEART JOURNAL, 129 (4). pp. 766-773. ISSN 0002-8703,
Full text not available from this repository.Abstract
Urodilatin [ANP-95-126] is a new natriuretic peptide of renal origin not subjected to tolerance in experimental congestive heart failure (CHF). To evaluate its therapeutic potentials in CHF, we investigated the efficacy of a prolonged infusion of urodilatin (15 ng/kg/min for 10 hours) in 12 patients with CHF (New York Heart Association functional classes II and III) in a randomized, double-blind, placebo-controlled study. Urodilatin elevated plasma cyclic guanosine monophosphate (cGMP) concentrations and increased urinary cGMP excretion. Systolic blood pressure (121 +/- 9 mm Hg to 111 +/- 7 mm Hg) and central venous pressure (7.4 +/- 3.3 mm Hg to 5.2 +/- 3.4 mm Hg) decreased significantly, and diastolic blood pressure and heart rate remained unchanged. Urine flow (0.7 +/- 0.6 ml/min to 1.5 +/- .6 ml/min) and urinary sodium excretion (48 +/- 16 mu mol/min to 180 +/- 97 mu mol/min) were significantly increased. Plasma norepinephrine, renin, aldosterone, and vasopressin were unaltered. The substance was well tolerated. Thus prolonged infusion of urodilatin lowers preload and increases diuresis and natriuresis without neurohumoral activation or adverse side effects, demonstrating a profile of effects that may be beneficial in patients with CHF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATRIAL-NATRIURETIC-PEPTIDE; PLASMA-LEVELS; HEALTHY-VOLUNTEERS; RAT-KIDNEY; ENDOCRINE; DOGS; ANP; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52606 |
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