SCHELENZ, G and ENGEL, J and RUPPRECHT, H (1995) SUBLIMATION DURING LYOPHILIZATION DETECTED BY TEMPERATURE PROFILE AND X-RAY TECHNIQUE. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 113 (2). pp. 133-140. ISSN 0378-5173,
Full text not available from this repository.Abstract
The goal of the investigation was to obtain a more precise picture of the processes in a vial during lyophilization. The sublimation front during freeze-drying of a mannitol solution could be inferred from a temperature profile, according to which the ice sublimates mainly from top to bottom, and, to a lesser extent, from outside to inside. These findings contradict the previous assumption that the sublimation front proceeds symmetrically from all sides, in a spherical fashion. Apart from glass, other container materials (aluminium and plastic) were also tested. The process of sublimation is the same, except that aluminium speeds up the process of drying while the isolating plastic slows it down. In order to check these results, X-ray photographs were taken at different points of time during primary drying. They confirm the results obtained from the temperature profile.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; FREEZE-DRYING; LYOPHILIZATION; SUBLIMATION; TEMPERATURE PROFILE; HEAT TRANSFER; MASS TRANSFER |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52794 |
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