Mansur, Ashham and Steinau, Maximilian and Popov, Aron Frederik and Milenovic, Sinisa and Bireta, Christian and Weymann, Alexander and Schotola, Hanna and Wiese, Christoph H. and Beissbarth, Tim and Tzvetkov, Mladen and Hinz, Jose (2015) Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery. PLOS ONE, 10 (6): e0131155. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Genetic variants within the endothelin-1 gene (EDN1) have been associated with several cardiovascular diseases and may act as genetic prognostic markers. Here, we explored the overall relevance of EDN1 polymorphisms for long-term survival in patients undergoing on-pump cardiac surgery. A prospectively collected cohort of 455 Caucasian patients who underwent cardiac surgery with cardiopulmonary bypass was followed up for 5 years. The obtained genotypes and inferred haplotypes were analyzed for their associations with the five-year mortality rate (primary endpoint). The EDN1 T-1370G and K198N genotype distributions did not deviate from Hardy-Weinberg equilibrium and the major allele frequencies were 83% and 77%, respectively. The cardiovascular risk factors were equally distributed in terms of the different genotypes and haplotypes associated with the two polymorphisms. The five-year mortality rate did not differ among the different EDN1 T-1370G and K198N genotypes and haplotypes. Haplotype analysis revealed that carriers of the G-T (compound EDN1 T-1370G G/K198N T) haplotype had a higher cardiac index than did non-carriers (p = 0.0008); however, this difference did not reach significance after adjusting for multiple testing. The results indicate that common variations in EDN1 do not act as prognostic markers for long-term survival in patients undergoing on-pump cardiac surgery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; PLASMA ENDOTHELIN; ATHEROSCLEROSIS; ASSOCIATION; LYS198ASN; VARIANT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Jul 2019 12:58 |
| Last Modified: | 10 Jul 2019 12:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5290 |
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