Jung, Ernst Michael and da Silva, Natascha Platz Batista and Jung, Wolfgang and Farkas, Stefan and Stroszczynski, Christian and Rennert, Janine (2015) Is Strain Elastography (IO-SE) Sufficient for Characterization of Liver Lesions before Surgical Resection-Or Is Contrast Enhanced Ultrasound (CEUS) Necessary? PLOS ONE, 10 (6): e0123737. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Aim To evaluate the diagnostic accuracy of IO-SE in comparison to IO-CEUS for the differentiation between malignant and benign liver lesions. Material and Methods In a retrospective diagnostic study IO-CEUS and SE examinations of 49 liver lesions were evaluated and compared to histopathological examinations. Ultrasound was performed using a multifrequency linear probe (6-9 MHz). The loops of CEUS were evaluated up to 5 min. The qualitative characterization of IO-SE was based on a color coding system (blue = hard, red = soft). Stiffness of all lesions was quantified by a specific scaling of 0-6 (0 = low, 6 = high) using 7 ROIs (2 central, 5 peripheral). Results All malignant lesions displayed a characteristic portal venous washout and could be diagnosed correctly by IO-CEUS. 3/5 benign lesions could not be characterized properly either by IO-CEUS or IO-SE prior to resection. Thus for IO-CEUS sensitivity, specificity, positive and negative predictive value and accuracy were 100%, 40%, 94%, 100% and 94%. Lesion sizes were between 8 and 59 mm in diameter. Regarding the IO-SE, malignant lesions showed a marked variability. In qualitative analysis, 31 of the malignant lesions were blue colored denoting overall induration. Thirteen malignant lesions showed an inhomogenous color pattern with partial indurations. Two of the benign lesions also displayed overall induration. The other benign lesions showed an inhomogenous color mapping. Calculated sensitivity of the SE was 70.5%, specificity 60%, PPV 94%, NPV 18.75%, and accuracy 69%. Conclusion IO-CEUS is useful for localization and characterization of liver lesions prior to surgical resection whereas IO-SE provided correct characterization only for a limited number of lesions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRAOPERATIVE ULTRASONOGRAPHY; COLORECTAL-CANCER; EFSUMB GUIDELINES; CLINICAL-USE; METASTASES; RECOMMENDATIONS; SONOGRAPHY; PRINCIPLES; SURGERY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Jul 2019 13:06 |
| Last Modified: | 10 Jul 2019 13:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5295 |
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