PFAU, A and ECKERT, F and SCHROPFER, T and RUSCHOFF, J (1994) VALUE OF THE ANALYSIS OF NUCLEOLUS-ORGANIZING REGIONS IN DERMATO-ONCOLOGY. HAUTARZT, 45 (11). pp. 762-768. ISSN 0017-8470,
Full text not available from this repository.Abstract
Nucleolus-organizing regions (AgNORs) are silver-stained loops of DNA transcribing to ribosomal RNA. Quantitative analysis helps to differentiate normal tissue from malignant tissue and can be used for diagnosis in several kinds of tumours. The analysis of AgNORs can also be used in dermatopathology for diagnostic and prognostic purposes. Apart from skin tumours such as basal,cell carcinomas and squamous cell carcinomas, this technique is of interest principally for melanocytic lesions. Benign naevi can be distinguished from malignant melanomas by simple counting of the AgNOR dots. For the differentiation of dysplastic naevi, Spitz naevi and malignant melanomas, this parameter alone is not sufficient. By combination of several AgNOR parameters (number, size, pattern of dispersal) only, significant differentiation could be achieved. The prognostic value of AgNORs remains to be examined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CUTANEOUS MELANOCYTIC LESIONS; MALIGNANT-MELANOMA; CELL CARCINOMA; PROTEINS; AGNORS; BENIGN; NEVI; TUMORS; COUNTS; SKIN; NUCLEOLUS; ORGANIZING REGIONS AGNORS; DERMATOPATHOLOGICAL DIAGNOSTICS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/52998 |
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