SCHRICKER, K and DELLABRUNA, R and HAMANN, M and KURTZ, A (1994) ENDOTHELIUM-DERIVED RELAXING FACTOR IS INVOLVED IN THE PRESSURE CONTROL OF RENIN GENE-EXPRESSION IN THE KIDNEY. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 428 (3-4). pp. 261-268. ISSN 0031-6768,
Full text not available from this repository.Abstract
To study the influence of endothelium derived relaxing factor/nitric oxide (EDNO) on renin gene expression, the effects of a 2-day treatment with the NO-synthase inhibitor nitro-L- arginine-methylester (L-NAME, 40 mg/kg twice a day) on plasma renin activity (PRA) and renal and adrenal renin m-RNA levels were examined in conscious rats with and without unilateral renal clips (0.2 mm). In sham-clipped animals L-NAME led to a decrease of PRA from 7.5 to 2.5 ng angiotensin I (ANGI).h(-1).ml(-1) and to a 35% decrease of renal renin m-RNA levels. Unilateral renal artery clipping increased PRA to 35 and to 13 ng ANGI.h(-1).ml(-1) in vehicle and in L-NAME-treated rats, respectively. In the clipped kidneys renin m-RNA levels increased to 450% of control values in vehicle-treated animals and to 220% of control values in L-NAME-treated animals. In the contralaterals as opposed to clipped kidneys, renin m-RNA levels decreased to 16% and 50% of the control values in vehicle- and in L-NAME-treated animals, respectively. In the adrenal glands renin m-RNA levels were not significantly changed either by clipping of one renal artery or by treatment of animals with L-NAME. The NO-donor sodium nitroprusside (100 mu M) was found to increase renin secretion and renin m-RNA levels in primary cultures of renal juxtaglomerular cells. These findings suggest that EDNO is involved in the control of the renin gene by the renal perfusion pressure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; SECRETION; RELEASE; CELLS; HYPERTENSION; INVIVO; DOGS; JUXTAGLOMERULAR CELLS; EDRF; RAAS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53065 |
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