BEDNARSKI, PJ and TRUMBACH, B (1994) USE OF REVERSED-PHASE HPLC FOR DETERMINATION OF THE HYDROLYSIS RATE CONSTANTS OF DICHLORO(1,2-DIARYLETHYLENEDIAMINE)PLATINUM(II) COMPLEXES. TRANSITION METAL CHEMISTRY, 19 (5). pp. 513-517. ISSN 0340-4285,
Full text not available from this repository.Abstract
The rates of the Pt-Cl hydrolysis reactions for a series of dichloro(1,2-diarylethylenediamine)platinum(II) complexes were measured by means of a reversed-phase h.p.l.c. assay. The compounds were hydrolysed at rates comparable to those published for [PtCl2(en)]. The configuration of the 1,2-diarylethylenediamine ligand (meso versus racem), as well as the type of substituent (i.e. OMe, CN or F) in the para-position of the aromatic rings had only a marginal influence on the rates of hydrolysis; however, the introduction of ortho-chloro substituents onto the aromatic rings markedly slowed the hydrolysis reactions. In contrast to the reported pH-dependency of the hydrolysis rates of cisplatin, changes in proton concentration had no effect on the hydrolysis rates of the title compounds over a pH range of 2.2-7.2. The activation parameters Delta H-not equal and Delta S-not equal of the Pt-Cl hydrolysis rates were comparable to those reported for similar Pt-II compounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MIXED-AMINE CISPLATIN; AQUEOUS CHEMISTRY; CIS-DICHLORODIAMMINEPLATINUM(II); PRODUCTS; RING; CIS-DIAMMINEDICHLOROPLATINUM(II); NUCLEOPHILES; KINETICS; ANALOGS; DNA; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53074 |
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