KOHLER, SM and KRAMER, BK (1994) CURRENT THERAPEUTIC MANAGEMENT OF DIABETIC NEPHROPATHY. ACTA DIABETOLOGICA, 31 (3). pp. 119-125. ISSN 0940-5429,
Full text not available from this repository.Abstract
Roughly 40% of all patients with insulin-dependent diabetes mellitus (IDDM) develop diabetic nephropathy with proteinuria, hypertension and a decrease in glomerular filtration rate 10 to 20 years after the onset of the disease, and 5 years later most patients suffer from end-stage renal disease. Microalbuminuria, defined as an urinary albumin excretion rate (UAER) between 30 and 300 mg/day, strongly predicts the development of nephropathy in IDDM. Nearly all patients with IDDM, a decreasing glomerular filtration rate and a UAER > 300 mg/day have coexisting hypertensive disease additionally worsening renal function. We review the results of recent long-term studies of the current therapeutic management in diabetic patients by means of better blood pressure control, low-protein diet and near-normal blood glucose control in the early microalbuminuric phase as well as in the later phases of the disease characterized by diabetic nephropathy with a UAER > 300 mg/day. Since the large majority of studies have been performed on IDDM, our conclusions with regard to therapy are only valid in this subgroup of diabetic patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIETARY-PROTEIN RESTRICTION; INSULIN DEPENDENT DIABETICS; CONVERTING ENZYME-INHIBITION; KIDNEY-FUNCTION; PERSISTENT MICROALBUMINURIA; ANTIHYPERTENSIVE TREATMENT; ALBUMIN EXCRETION; METABOLIC CONTROL; RENAL-FAILURE; MELLITUS; DIABETIC NEPHROPATHY; ACE INHIBITOR; PROTEIN RESTRICTION; MICROALBUMINURIA |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53086 |
Actions (login required)
 |
View Item |
