REMOVAL OF THE PYRROLIDINE SUBSTITUENT BY DEHYDROGENATION OF 4-PYRROLIDIN-2-YL-3,4-DIHYDRO-TETRAHYDROISOQUINOLINE AND 1,2,3,4-TETRAHYDROISOQUINOLINE

MAHBOOBI, S and KARCHER, A and GROTHUS, G and WAGNER, W and WIEGREBE, W (1994) REMOVAL OF THE PYRROLIDINE SUBSTITUENT BY DEHYDROGENATION OF 4-PYRROLIDIN-2-YL-3,4-DIHYDRO-TETRAHYDROISOQUINOLINE AND 1,2,3,4-TETRAHYDROISOQUINOLINE. ARCHIV DER PHARMAZIE, 327 (7). pp. 417-428. ISSN 0365-6233, 1521-4184

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Abstract

Pyrrolidin-2-yl-groups located at C-4 of 3,4-dihydro- or 1,2,3,4-tetrahydroisoquinolines, respectively, are lost in the course of dehydrogenation of these isoquinoline derivatives. However, acyclically substituted isoquinolines, hydrogenated in ring B, 2-benzyl-4-(1-dimethylaminoethyl)-1,2,3,4-tetrahydroisoquinoline, e.g., show loss of the amine group only by benzylic cleavage, affording 4-ethylisoquinoline. Scope and limitation of this reaction are determined using specifically substituted isoquinolines.

Item Type: Article
Uncontrolled Keywords: ;
Depositing User: Dr. Gernot Deinzer
Last Modified: 19 Oct 2022 08:40
URI: https://pred.uni-regensburg.de/id/eprint/53204

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