STRAUB, RH and ELBRACHT, R and KRAMER, BK and ROTH, M and PALITZSCH, KD and SCHOLMERICH, J (1994) INFLUENCE OF DIGOXIN-LIKE IMMUNOREACTIVE FACTOR ON LATE COMPLICATIONS IN PATIENTS WITH DIABETES-MELLITUS. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 24 (7). pp. 482-487. ISSN 0014-2972,
Full text not available from this repository.Abstract
The aim of this study was to compare the intensity of typical late complications in diabetic patients (n = 65, 28 type I, 37 type II) who were not on glycoside drugs with low vs. high serum levels of digoxin-like immunoreactive factor (DLIF: group I, n = 42, DLIF less than or equal to the detection limit of 0.2 ng ml(-1); and group II, n = 23, mean +/- SEM: 1.17 +/- 0.31 [0.25-4.96] ng ml(-1)). For detection of nephropathy, urinary albumin excretion (24 h) and creatinine clearance tests were used. For coronary heart disease a questionnaire and standard ECG; for peripheral occlusive vascular disease a questionnaire; for eye disease a fundoscopy; for neuropathy a neurological score system; and for autonomic neuropathy a standardized test battery was employed. Patients with high DLIF levels showed better test results in vibratory perception (95.7 +/- 1.5 vs. 82.8 +/- 3.8%, normal finding=100%, 2p = 0.016), had better percentile localizations concerning maximal pupillary area in darkness (28.4 +/- 6.6 vs. 8.1 +/- 1.8%, 2p=0.0004), contraction velocity at 1 s (21.5 +/- 5.8 vs. 8.0 +/- 2.2%, 2p=0.012), and dilation velocity at 6 s (23.0 +/- 6.8 vs. 10.5 +/- 2.5%, 2p=0.041), had less retinopathy (with retinopathy: 26.1% vs. 64.3%, 2P=0.0028), and better percentile localizations in the respiratory sinus arrhythmia test (684 +/- 7.3 vs. 44.1 +/- 4.9%, 2p = 0.0064). There was no difference concerning nephropathy, blood pressure, coronary heart disease and peripheral vascular disease. Separate analysis according to the type of diabetes confirmed the results in each group. This would indicate that DLIF is a possible protective endogenous substance for eye disease, and peripheral (large sensory fibres) and autonomic neuropathy in diabetic subjects independent of the type of diabetes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIGITALIS-LIKE SUBSTANCE; LIVER-DISEASE; ESSENTIAL-HYPERTENSION; TRANSPORT INHIBITOR; PUMP INHIBITOR; HUMAN-PLASMA; SERUM; IMMUNOASSAY; ALDOSTERONE; COMPOUND; DIABETIC CARDIOVASCULAR DISEASE; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DIGOXIN-LIKE IMMUNOREACTIVE FACTOR |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53208 |
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