MUSCHOLL, MW and MUDERS, F and KOHLER, SM and KROMER, EP and ELSNER, D and KRAMER, BK and RIEGGER, GAJ (1994) LEFT-VENTRICULAR HYPERTROPHY, HUMORAL ACTIVATION AND HEMODYNAMICS IN ARTERIAL-HYPERTENSION. NIEREN-UND HOCHDRUCKKRANKHEITEN, 23 (4). pp. 149-151. ISSN 0300-5224,
Full text not available from this repository.Abstract
To assess humoral activation and systemic hemodynamics in different patterns of left ventricular (LV) hypertrophy 92 patients with arterial hypertension were investigated by echocardiography. Enddiastolic diameter, relative wall thickness (rWth), LV mass index, cardiac output (CO) and peripheral resistance were determined. Plasma renin activity, aldosterone and ANF were measured by RIA. Patients were characterized as having no hypertrophy (normal rWth, normal M), LV Remodeling (increased rWth, normal M), concentric hypertrophy (increased rWth, increased M), eccentric hypertrophy (normal rWth, increased M). Renin activity was not different between the groups. Highest values of aldosterone and ANF were found in eccentric hypertrophy with a dilated LV, increased CO and mildly increased peripheral resistance. Increased ANF and normal aldosterone were detected in concentric hypertrophy with a normal LV, CO, and increased resistance. Increased aldosterone and normal ANF values, a small LV with reduced CO and markedly increased peripheral resistance were found in patients with LV Remodeling. Normal aldosterone and ANF were present in patients without hypertrophy with a normal LV, CO, and increased resistance. Thus, different patterns of LV hypertrophy demonstrate different humoral activation and systemic hemodynamics. Our data suggest, that a combined pressure and volume overload is present in patients with eccentric hypertrophy. In patients with LV Remodeling who are supposed to represent pressure overload and volume underloading, increased aldosterone might represent a counterregulatory mechanism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; ARTERIAL HYPERTENSION; LEFT VENTRICULAR HYPERTROPHY; ANF; ALDOSTERONE; SYSTEMIC HEMODYNAMICS; ECHOCARDIOGRAPHY |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53385 |
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