MAHBOOBI, S and GROTHUS, G and MEINDL, W (1994) INDOLE-DERIVATIVES WITH ANTIMYCOBACTERIAL ACTIVITY. ARCHIV DER PHARMAZIE, 327 (2). pp. 105-114. ISSN 0365-6233,
Full text not available from this repository.Abstract
1,3-Dinitro-2-(indol-3'-yl)-propanes 3 are synthesized by Michael reaction of nitromethane with the indolylnitroethenes 2. - Reaction of the aldehydes 4 and 10 with the benzylamines 12 as well as the reaction of the indolylal-kylamines 6a and 9a with the benzaldehydes 11 lead to Schiff bases which are reduced to N-benzyl-(indol-3-ylmethyl)-amines 13 and N-benzyl(indol-3-ylethyl)-amines 14, respectively; tert amines 16 are synthesized via the formamides 15, amines 18 are prepared according to Mannich. Inhibitory effects on Mycobacterium tuberculosis H 37 Ra are investigated, a structure-activity relationship is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BENZYLAMINES; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53469 |
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