BEYER, ME and NERZ, S and KRAMER, BK and HOFFMEISTER, HM (1994) HEMODYNAMIC AND INOTROPIC EFFECTS OF ENDOTHELIN-1 IN-VIVO. BASIC RESEARCH IN CARDIOLOGY, 89 (1). pp. 39-49. ISSN 0300-8428,
Full text not available from this repository.Abstract
Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10000 ng ET-1/kg vs. NaCl controls) hemodynamic and inotropic effects of ET-1 in 53 open-chest rats during and after a 7-min infusion. Besides measurements in the intact circulation the myocardial function was examined by isovolumic registrations independent of peripheral vascular effects. A transient ET-1 induced (500, 1000, 2500, 5000 ng ET-1/kg) decrease of the left ventricular systolic pressure (LVSP) and the mean aortic pressure (AoP(mean)) was followed by a dose-related rise of these pressures (LVSP: -1%, -1%, +8%, +16% vs. preinfusion values; AoP(mean): -11%, +9%, +39%, +52%). Heart rate (HR) was not influenced by ET-1. Due to the dose-dependent decrease of the stroke volume (SV) the cardiac output (CO) was reduced (CO: -8%, -23%, -40%, -50%). After an initial vasodilatation ET-1 elevates the total peripheral resistance (TPR: -1%, +49%, +139%, +215%) dose-dependently, 10000 ng ET-1/kg was a lethal dose resulting in cardiac failure within minutes (low output). Since the maximum of the isovolumic LVSP (peak LVSP) and the corresponding dP/dt(max) (peak dP/dt(max)) were unchanged under ET-1, the isovolumic measurements do not indicate a positive inotropic effect of ET-1 in vivo in contrast to published results of in vitro experiments. It may be possible that a direct positive inotropic effect of ET-1 observed in in vitro studies is counterbalanced in vivo by an indirect negative inotropic effect due to the coronar-constrictive effect of ET-1.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASOCONSTRICTOR PEPTIDE ENDOTHELIN; PERFUSED RAT-HEART; INTRAVENOUS ENDOTHELIN; NORMOTENSIVE RATS; CELLS; CONTRACTILITY; PROSTACYCLIN; MYOCYTES; RELEASE; ATRIA; ENDOTHELIN-1; HEMODYNAMIC EFFECTS; INOTROPIC EFFECTS; ISOVOLUMIC MEASUREMENTS; RATS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53530 |
Actions (login required)
 |
View Item |
