GLIESE, M and BABINEBELL, J and SCHOMIG, E and RUSS, H (1994) THE NEURONAL TRANSPORT MECHANISM FOR NORADRENALINE IS NOT INFLUENCED BY THE ATP ANALOG ATP-GAMMA-S. [["eprint_typename_letter" not defined]]
Full text not available from this repository.Abstract
Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake(1)). There are reports which describe the activity of uptake(1) being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a modulation of uptake(1) by extracellular ATP would be of great physiological relevance. In clonal rat pheochromocytoma cells (PC12) we determined the kinetic parameters, K-m and V-max, of noradrenaline transport in the absence and presence of ATP gamma S. The addition of 0.1 mu mol/L ATP gamma S had no effect on initial rates of specific noradrenaline transport. Only a slightly increased non-specific noradrenaline flux in the presence of ATP gamma S could be observed. On the basis of our results, there is no evidence for the modulation of the uptake(1) carrier by ATP gamma S.
| Item Type: | ["eprint_typename_letter" not defined] |
|---|---|
| Uncontrolled Keywords: | PHEOCHROMOCYTOMA CELLS; PLASMA-MEMBRANE; NORADRENALINE TRANSPORT; ATP; ATP-GAMMA-S |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53576 |
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