Haimerl, Michael and Utpatel, Kirsten and Verloh, Niklas and Zeman, Florian and Fellner, Claudia and Nickel, Dominik and Teufel, Andreas and Fichtner-Feigl, Stefan and Evert, Matthias and Stroszczynski, Christian and Wiggermann, Philipp (2017) Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis. SCIENTIFIC REPORTS, 7: 41429. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions and has recently received increasing attention as a tool for the quantitative analyses of liver function. We report the relationship between the extent of Gd-EOB-DTPA-induced T1 relaxation and the degree of liver fibrosis, which was assessed according to the METAVIR score. For the T1 relaxometry, a transverse 3D VIBE sequence with inline T1 calculation was acquired prior to and 20 minutes after Gd-EOB-DTPA administration. The reduction rates of the T1 relaxation time (rrT1) between the pre- and postcontrast images were calculated, and the optimal cutoff values for the fibrosis stages were determined with receiver operating characteristic (ROC) curve analyses. The rrT1 decreased with the severity of liver fibrosis and regression analysis revealed a significant correlation of the rrT1 with the stage of liver fibrosis (r = -0.906, p < 0.001). ROC analysis revealed sensitivities >= 78% and specificities >= 94% for the differentiation of different fibrosis stages. Gd-EOB-DTPA-enhanced T1 relaxometry is a reliable tool for both the detection of initial hepatic fibrosis and the staging of hepatic fibrosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORGANIC ANION TRANSPORTERS; CHRONIC HEPATITIS-C; T1 RELAXATION-TIME; CONTRAST AGENT; 3 TESLA; PARENCHYMAL ENHANCEMENT; QUANTITATIVE-EVALUATION; CIRRHOSIS; ELASTOGRAPHY; PHASE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 25 Feb 2019 11:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/536 |
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