SCHRICKER, K and RITTHALER, T and KRAMER, BK and KURTZ, A (1993) EFFECT OF ENDOTHELIUM-DERIVED RELAXING FACTOR ON RENIN SECRETION FROM ISOLATED MOUSE RENAL JUXTAGLOMERULAR CELLS. ACTA PHYSIOLOGICA SCANDINAVICA, 149 (3). pp. 347-354. ISSN 0001-6772,
Full text not available from this repository.Abstract
This study aimed to examine the direct influence of native endothelium derived relaxing factor (EDRF) on renin secretion. To this end isolated mouse renal juxtaglomerular cells were cocultured with bovine aortic endothelial cells which produced and released significant amounts of EDRF as assayed by guanylate cyclase activities which were measured separately in endothelial and juxtaglomerular cells as well as in the cocultures of juxtaglomerular with endothelial cells. EDRF production was blunted in the absence of extracellular L-arginine and in the presence of N(omega)nitro-L-arginine (L-NAG; 200 muM). Inhibition of endothelial EDRF production by removal of arginine or addition Of L-NAG was associated with a significant decrease of renin secretion from the cocultures while the same regimen had no effect on renin secretion from JG cells alone. Exogeneous generation of nitric oxide by the addition of sodium nitroprusside (100 mum) stimulated renin secretion in the cocultures both at normal and inhibited EDRF formation as well as from juxtaglomerular cells alone. These findings suggest that native EDRF released from vascular endothelial cells is a stimulatory signal for renin secretion from renal juxtaglomerular cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; PERFUSED RAT-KIDNEY; L-ARGININE; RELEASE; CALCIUM; STIMULATION; BRADYKININ; INVITRO; JUXTAGLOMERULAR CELLS; RENIN RELEASE; EDRF |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53681 |
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