SRCIC, S and RUPPRECHT, H and DACA, J and SMIDKORBAR, J (1993) CHEMISORBATES OF P-HYDROXYBENZOIC ACID METHYL-ESTER ON SILICA AS A NEW-TYPE OF PRO-DRUG .4. DRUG-RELEASE FROM CHEMISORBATES DISPERSED IN LIPOPHILIC VEHICLES. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 99 (1). pp. 21-28. ISSN 0378-5173,
Full text not available from this repository.Abstract
The hydrolysis of the chemisorbate of p-hydroxybenzoic acid methyl ester (PHBAME) on porous silica (KG 100) incorporated in lipophilic vehicles such as liquid paraffin, synthetic oil Miglyol(R) 818 and white petrolatum was examined in dissolution media at pH 2 and 7.4, respectively. Chemisorbed PHBAME on KG 100 is released more rapidly in alkaline than in acidic dissolution fluids. Dispersions of the PHBAME-KG 100 chemisorbate in lipophilic vehicles modify the hydrolysis significantly. Drug release from chemisorbate dispersed in lipophilic vehicles may be controlled by the polarity of the vehicles. However, the viscosity of the vehicle, and not the polarity, exerts the strongest influence on the drug release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMOBILIZED DRUGS; AQUEOUS-SOLUTION; CHEMIADSORBATES; ADSORBATES; CHEMISORBATE; POROUS SILICA RELEASE; P-HYDROXYBENZOIC ACID METHYL ESTER; RELEASE KINETICS; LIPOPHILIC DISPERSION; DRUG RELEASE DELAY |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53802 |
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