Laengst, Gernot and Manelyte, Laura (2015) Chromatin Remodelers: From Function to Dysfunction. GENES, 6 (2). pp. 299-324. ISSN 2073-4425
Full text not available from this repository. (Request a copy)Abstract
Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of different enzymes and chromatin remodeling complexes exist in the cell, the particular remodeling complex with its specific nucleosome positioning features must be at the right place at the right time in order to ensure the proper regulation of the DNA dependent processes. To achieve this, chromatin remodeling complexes harbor protein domains that specifically read chromatin targeting signals, such as histone modifications, DNA sequence/structure, non-coding RNAs, histone variants or DNA bound interacting proteins. Recent studies reveal the interaction between non-coding RNAs and chromatin remodeling complexes showing importance of RNA in remodeling enzyme targeting, scaffolding and regulation. In this review, we summarize current understanding of chromatin remodeling enzyme targeting to chromatin and their role in cancer development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RIBOSOMAL-RNA GENES; TWIST-DIFFUSION MECHANISM; NUCLEOSOME CORE PARTICLE; DOUBLE-STRAND BREAKS; SMALL-CELL CARCINOMA; COMPLEX NORC; DNA-SEQUENCE; SOMATIC MUTATIONS; SWI/SNF COMPLEX; PROSTATE-CANCER; chromatin remodeler; cancer; search mechanism; arrest model; non-coding RNA |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Aug 2020 06:43 |
| Last Modified: | 21 Aug 2020 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5382 |
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