MULLER, R and BOCK, HL and CLEMENS, R and JILG, W (1993) ACTIVE IMMUNIZATION AGAINST HEPATITIS-A - COMPARISON OF DIFFERENT IMMUNIZATION SCHEDULES. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 118 (31). pp. 1101-1104. ISSN 0012-0472, 1439-4413
Full text not available from this repository.Abstract
Three different immunization schedules were compared in 144 young, healthy adults (81 men, 63 women; mean age 28.5 years). They were randomly assigned to one of three groups: group 1, immunization shots on day 0 and day 14 (n = 47), group 2, on day 0 and day 28 (n = 50), and group 3, on day 0, 14 and 28 (n = 47). All participants had a booster shot after one year. The seroconversion rate was 40-46% after first shot, 95-100% after the second one; all were anti-HAV positive after the booster injection. All subjects had specific antibodies in a mean concentration of > 400 IU/l two weeks after the second shot. In almost all subjects antibodies were demonstrable up to the 12th month after the first immunization (> 20 IU/l). Mean antibody concentration during the interval between the second and third immunization after basal immunization on day 0 and 14 or 0 and 28, respectively, was comparable. Three initial immunizations 14 days apart did not achieve much higher anti-HAV levels. The vaccine was equally well tolerated in all three groups. Thus basal immunization shortened to two injections two weeks apart presents a good alternative to the standard scheme of two injections four weeks apart. Three injections two weeks apart bring no demonstrable advantage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VACCINE; IMMUNOGENICITY; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53832 |
Actions (login required)
 |
View Item |
