KRITZENBERGER, J and ZIMMERMANN, F and WOKAUN, A (1993) H-1-NMR AND VIBRATIONAL-SPECTRA OF CIS-DICHLOROBIS(CYCLOALKYLAMINE)-PLATINUM(II) COMPLEXES. INORGANICA CHIMICA ACTA, 210 (1). pp. 47-56. ISSN 0020-1693, 1873-3255
Full text not available from this repository.Abstract
The H-1 NMR and vibrational spectra of the complexes PtCl2(am)2, with am=cycloalkylamine (CnH2n-1NH2, n = 3, 4, 5, 6, 7, 8) are reported. The anisotropic effects of the cyclopropylamine ligand on the H-1 chemical shifts are discussed. Most of the IR and Raman active modes observed for the complexes are assigned by comparison with the vibrational spectra of the pure amine ligands. Shifts of the internal ligand frequencies are explained by effects resulting from the coordination of the amino group to the Pt atom. The Pt-N stretching frequency is observed to decrease in a non-monotonic manner with increasing cycloalkylamine ring size. The frequencies of the Pt-Cl stretching vibrations do not differ significantly for the different complexes, while the antitumor activity has been found to increase strongly for the complexes with the largest ligands (n = 7 and 8). Implications of this finding for the mechanism of cytostatic action by DNA binding are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLATINUM COMPLEXES; CIS; CRYSTAL; TRANS; DNA; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53850 |
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