LIEBERS, V and RAULF, M and MAZUR, G and MODROW, S and BAUR, X (1993) EPITOPE MAPPING WITH PEPTIDES OF CHI-T-I COMPONENT-III AND IMMUNOMODULATION OF THE CHI-T IMMUNE-RESPONSE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 92 (2). pp. 334-339. ISSN 0091-6749,
Full text not available from this repository.Abstract
Background: Hemoglobins of the Diptera family are known as aggressive inhalant allergens. Methods: The whole sequence of the insect allergen Chi t I component III was studied for T-cell epitope activity in cell cultures of 15 sensitized patients with a panel of 17 overlapping synthetic peptides and 12 peptides obtained by tryptic cleavage. Results: All but one of the peptides tested were found to be immunogenic. The nonstimulatory sequence 102-109 and two other tryptic peptides (69-90 and 110-135) were used in inhibition experiments. The Chi t I-induced proliferation was downregulated by all tested peptides when compared with stimulation with Chi t I alone. Conclusions: Because stimulation with phytohemagglutinin or tetanus toxoid was not influenced by the above-mentioned peptides, this mechanism seems to be specific for the antigen. Specific immunomodulation with nonstimulating peptides may offer new therapy approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL EPITOPES; ANTIGEN; HEMOGLOBIN; SEQUENCE; ERYTHROCRUORIN; RECOGNITION; COMPETITION; ALLERGENS; MOLECULES; PROTEINS; ALLERGEN; T-CELL EPITOPE; CHI-T-I COMPONENT-III; IMMUNOMODULATION |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53852 |
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