GUST, R and SCHONENBERGER, H (1993) MAMMARY-TUMOR INHIBITING [1,2-BIS(2,6-DIHALO-3-HYDROXYPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. RELATIONSHIP BETWEEN STRUCTURE AND ESTROGENIC ACTIVITY OF THE DIAMINE LIGANDS, THEIR SULFATOPLATINUM(II) AND DIIODOPLATINUM(II) COMPLEXES. ARCHIV DER PHARMAZIE, 326 (7). pp. 405-413. ISSN 0365-6233,
Full text not available from this repository.Abstract
1,2-Bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamines with 2,6-Cl2, 2-F,6-Cl, 2-Cl,6-F, and 2,6-F2 substituents (meso-1 to meso-4, D,L-1 and D,L-4) and their sulfatoplatinum(II) complexes were tested in the immature mouse uterine weight test. The only complex with marked estrogenic properties proved to be meso-1-PtSO4. Surprisingly its diamine ligand meso-I was only marginally active. H-1-NMR spectroscopic studies on the 1,2-diphenylethylenediamine ligand reveal that the 2,6-standing Cl-atoms in meso-1 (antiperiplanar phenyl residues) hinder the rotation of the aromatic rings, which results in very stable conformers with different O-O distances owing to the unsymmetric arrangement of the ring substituents. On transformation into the Pt(II) complex the conformations of meso-I change (synclinal phenyl residues) and a delta and lambda interconversion takes place already at physiological temp. (37-degrees-C). This process is accompanied by a rotation of phenyl rings, which is supposed to allow an optimal fit for the formation of hydrogen bridges to the estrogen receptor, resulting in a marked estrogenic activity. The other ligands and complexes are inactive presumably due to a diminished hydrophobic interaction with the estrogen receptor, resulting from their R,R/S,S-configuration or the reduced number of Cl-atoms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTI-ESTROGENS; SD-RAT; CARCINOMA; CISPLATIN; ANTITUMOR; RING; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/53886 |
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