DIMETHYL 3,3'-(4-METHYL-1,3-NAPHTHYLENE)DIPROPIONATE AS A SINGLET OXYGEN TRAP IN BIOLOGICAL-SYSTEMS

MULLER, K and ZIEREIS, K (1993) DIMETHYL 3,3'-(4-METHYL-1,3-NAPHTHYLENE)DIPROPIONATE AS A SINGLET OXYGEN TRAP IN BIOLOGICAL-SYSTEMS. ARCHIV DER PHARMAZIE, 326 (6). pp. 369-371. ISSN 0365-6233,

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Abstract

The utility of dimethyl 3,3'-(4-methyl-1,3-naphthylene)dipropionate (DMNDP) as a singlet oxygen trap in biological systems is described. The determination of the rate constant for the reaction of DMNDP with singlet oxygen in acetonitrile gave a value of 9.8 - 10(-7) M-1s-1; the half-life of the corresponding endoperoxide at 37-degrees-C in phosphate buffered saline is 412 min. DMNDP does not possess sensitizing properties, and its usefulness for the detection of singlet oxygen is demonstrated in the photooxidation of liposomes by 5,10,15,20-tetraphenyl-21H,23H-porphine (TPP).

Item Type: Article
Uncontrolled Keywords: HYDROGEN-PEROXIDE;
Depositing User: Dr. Gernot Deinzer
Last Modified: 19 Oct 2022 08:42
URI: https://pred.uni-regensburg.de/id/eprint/53928

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