Liu, Teresa T. and Arango-Argoty, Gustavo and Li, Zhihua and Un, Yuefeng and Kim, Sang Woo and Dueck, Anne and Ozsolak, Fatih and Monaghan, A. Paula and Meister, Gunter and Defranco, Donald B. and John, Bino (2015) Noncoding RNAs that associate with YB-1 alter proliferation in prostate cancer cells. RNA, 21 (6). pp. 1159-1172. ISSN 1355-8382, 1469-9001
Full text not available from this repository. (Request a copy)Abstract
The highly conserved, multifunctional YB-1 is a powerful breast cancer prognostic indicator. We report on a pervasive role for YB-1 in which it associates with thousands of nonpolyadenylated short RNAs (shyRNAs) that are further processed into small RNAs (smyRNAs). Many of these RNAs have previously been identified as functional noncoding RNAs (http://www.johnlab.org/YB1). We identified a novel, abundant, 3'-modified short RNA antisense to Dicer1 (Shad1) that colocalizes with YB-1 to P-bodies and stress granules. The expression of Shad1 was shown to correlate with that of YB-1 and whose inhibition leads to an increase in cell proliferation. Additionally, Shad1 influences the expression of additional prognostic markers of cancer progression such as DLX2 and IGFBP2. We propose that the examination of these noncoding RNAs could lead to better understanding of prostate cancer progression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-BINDING PROTEIN-2; NUCLEAR-LOCALIZATION; TGF-BETA; EXPRESSION; GENE; PROGRESSION; MICRORNAS; REVEAL; DNA; POLYADENYLATION; YB-1; noncoding RNAs; miRNAs; prostate cancer |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2019 07:06 |
| Last Modified: | 15 Jul 2019 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5409 |
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