Aziz, Atiqullah and Kempkensteffen, Carsten and May, Matthias and Lebentrau, Steffen and Burger, Maximilian and Chun, Felix K-H and Brookman-May, Sabine (2015) Prognostic, predictive and potential surrogate markers in castration-resistant prostate cancer. EXPERT REVIEW OF ANTICANCER THERAPY, 15 (6). pp. 649-666. ISSN 1473-7140, 1744-8328
Full text not available from this repository. (Request a copy)Abstract
Several novel therapeutic agents have demonstrated improvement of overall survival and further patient relevant endpoints in the setting of castration-resistant prostate cancer. Nevertheless, two questions have become increasingly relevant: are there any prognostic or predictive markers that could ease clinical decision-making using risk stratification and risk-adapted treatment in order to provide a benefit for the patient? Furthermore, against the background of increasing possibilities of therapy sequencing in clinical practice and in the clinical trial landscape in castration-resistant prostate cancer, does an isolated evaluation of overall survival reliably mirror the benefit attributable to a single compound? To address both these questions, suitable parameters serving as surrogates for intermediate and long-term endpoints and reflecting individual benefit, respectively, need to be identified and proven.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCULATING TUMOR-CELLS; ANTIGEN DOUBLING TIME; TO-LYMPHOCYTE RATIO; ANHYDRASE IX CAIX; CLINICAL-TRIALS; END-POINTS; RADICAL PROSTATECTOMY; ABIRATERONE ACETATE; BONE METASTASES; ZOLEDRONIC ACID; biomarker; castration-resistant prostate cancer; clinical decision-making; clinical trials; predictive marker; prognostic marker; surrogate endpoint; surrogate marker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Aug 2020 06:37 |
| Last Modified: | 21 Aug 2020 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5412 |
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